<p>High Level of IL-10 in Cerebrospinal Fluid is Specific for Diagnosis of Primary Central Nervous System Lymphoma</p>

Cerebrospinal Fluid IL-10 and IL-10/IL-6 as Accurate Diagnostic Biomarkers for Primary Central Nervous System Large B-cell Lymphoma

Early diagnosis of primary central nervous system lymphoma (PCNSL) represents a challenge, and cerebrospinal fluid (CSF) cytokines may be diagnostic biomarkers for PCNSL. We used an electrochemiluminescence immunoassay to measure interleukin (IL)-10, IL-6, IL-8 and tumor necrosis factor α (TNF-α) in the CSF of 22 B cell PCNSL patients and 80 patients with other CNS diseases. CSF IL-10 was signi...

Biochemical markers of central nervous system tumors in cerebrospinal fluid.

Central nervous system (CNS) tumor markers that have been m easured in cerebrospinal fluid (CSF) include among others, lactate dehydrogenase (LDH), glutamic oxalacetic transaminase (GOT), aldolase, phosphohexose isomerase (PHI), lysozyme, creatinine kinase, isocitrate dehydrogenase, adenylate kinase, the polyamines and desmosterol. Such markers have at least five possible functions in the diagn...

Cerebrospinal fluid immunoglobulins in cysticercosis of the central nervous system.

Investigation on the behavior of immunoglobulins IGG, IGA and IGM in the CSF, in cases of cysticercosis of the CNS, based on data pertaining to two different series of cases. The first series comprises 30 samples of CSF, and the second one, 5 samples. It was demonstrated that IGG is the one representing the largest contingent. IGG concentration keeps in proportion with the gamma globulin concen...

Is Hemorrhagic Demyelinating Lesions of Central Nervous System a Spectrum?

Autoimmune Hemolytic Anemia preceding the Diagnosis of Primary Central Nervous System Lymphoma

In this study, a 2.5-year-old boy suffering from a febrile seizure with normal laboratory tests and a history of immune hemolytic anemia was examined. Brain MRI demonstrated some tumors in the frontal, parietal, and occipital lobe that corroborated the pathology results of primary central nervous system lymphoma for the patient. The patient was treated with high- dose of Methotrexate. Our re...